András Horváth

Experienced electrophysiologist and life science professional with a strong background in automated patch clamp technology, cardiac physiology, and high-throughput drug screening. Proven track record in both academic and industry settings, with expertise in assay development, in vitro and in vivo experimentation, and operation of advanced screening platforms. Skilled in scientific writing, grant applications, customer support, and international sales and marketing activities.

• Date of Birth: 04/10/87
• Nationality: Hungarian
• Marital Status: Married

• L-364,373 (R-L3) enantiomers have adverse modulating effects on IKs in mammalian ventricular myocytes, C. Corici, Zs. Kohajda, A. Kristóf, A. Horváth, L. Virág, T. Szél, N. Nagy, Zs. Szakonyi, F. Fülöp, D.M. Muntean, A. Varró, N. Jost, Canadian Journal of Physiology and Pharmacology, 10.1139/cjpp-2012-0407, 2013, X0-000
• ORM-10103, a novel specific inhibitor of the sodium/calcium exchanger, decreases early and delayed afterdepolarization in the canine heart, Jost N, Nagy N, Kohajda Z, Horvath A, Corici C, Acsai K, Biliczki P, Levijoki J, Pollesello P, Koskelainen T, Otsomaa L, Toth A, Papp JGy, Varro A, Virag L, British Journal of Pharmacology, 2013, 000-000
• LQT1-phenotypes in hiPSC: Are we measuring the right thing?, Christ T, Horvath A, Eschenhagen T, Proc Natl Acad Sci U S A, 04/21/15, 112, 16, E1968, 10.1073/pnas.1503347112, 25795242, PMC4413273
• A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant-negative mutation of the KCNE1 gene, Major P, Baczkó I, Hiripi L, Odening KE, Juhász V, Kohajda Z, Horváth A, Seprényi G, Kovács M, Virág L, Jost N, Prorok J, Ördög B, Doleschall Z, Nattel S, Varró A, Bősze Z, Br J Pharmacol, 06/01/16, 173, 12, 2046-61, 10.1111/bph.13500, 27076034, PMC4882500
• Ca(2+)-Currents in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Effects of Two Different Culture Conditions, Uzun AU, Mannhardt I, Breckwoldt K, Horváth A, Johannsen SS, Hansen A, Eschenhagen T, Christ T, Front Pharmacol, 09/12/16, 7, 300, 10.3389/fphar.2016.00300, 27672365, PMC5018497
• Low Resting Membrane Potential and Low Inward Rectifier Potassium Currents Are Not Inherent Features of hiPSC-Derived Cardiomyocytes, Horváth A, Lemoine MD, Löser A, Mannhardt I, Flenner F, Uzun AU, Neuber C, Breckwoldt K, Hansen A, Girdauskas E, Reichenspurner H, Willems S, Jost N, Wettwer E, Eschenhagen T, Christ T, Stem Cell Reports, 03/13/18, 10, 3, 822-833, 10.1016/j.stemcr.2018.01.012, 29429959, PMC5918194
• Disease modeling of a mutation in α-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy, Prondzynski M, Lemoine MD, Zech AT, Horváth A, Di Mauro V, Koivumäki JT, Kresin N, Busch J, Krause T, Krämer E, Schlossarek S, Spohn M, Friedrich FW, Münch J, Laufer SD, Redwood C, Volk AE, Hansen A, Mearini G, Catalucci D, Meyer C, Christ T, Patten M, Eschenhagen T, Carrier L, EMBO Mol Med, 12/01/19, 11, 12, e11115, 10.15252/emmm.201911115, 31680489, PMC6895603
• Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes-An Artifact by Big Conductance Calcium Activated Potassium Current (Ibk,Ca), Horváth A, Christ T, Koivumäki JT, Prondzynski M, Zech ATL, Spohn M, Saleem U, Mannhardt I, Ulmer B, Girdauskas E, Meyer C, Hansen A, Eschenhagen T, Lemoine MD, Cells, 01/20/20, 9, 1, 253, 10.3390/cells9010253, 31968557, PMC7017352
• Automated Dynamic Clamp for Simulation of IK1 in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Real Time Using Patchliner Dynamite8, Becker N, Horváth A, De Boer T, Fabbri A, Grad C, Fertig N, George M, Obergrussberger A, Curr Protoc Pharmacol, 03/01/20, 88, 1, e70, 10.1002/cpph.70, 31868992
• Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment, Rotordam MG, Obergrussberger A, Brinkwirth N, Takasuna K, Becker N, Horváth A, Goetze TA, Rapedius M, Furukawa H, Hasegawa Y, Oka T, Fertig N, Stoelzle-Feix S, J Pharmacol Toxicol Methods, 11/01/21, 112, 107125, 10.1016/j.vascn.2021.107125, 34500078
• In vivo and cellular antiarrhythmic and cardiac electrophysiological effects of desethylamiodarone in dog cardiac preparations, Kohajda Z, Virág L, Hornyik T, Husti Z, Sztojkov-Ivanov A, Nagy N, Horváth A, Varga R, Prorok J, Szlovák J, Tóth N, Gazdag P, Topal L, Naveed M, Árpádffy-Lovas T, Pászti B, Magyar T, Koncz I, Déri S, Demeter-Haludka V, Aigner Z, Ördög B, Patfalusi M, Tálosi L, Tiszlavicz L, Földesi I, Jost N, Baczkó I, Varró A, Br J Pharmacol, 02/01/22, 10.1111/bph.15812, 35106755
• Regulation of APD and Force by the Na+/Ca2+ Exchanger in Human-Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue, Ismaili D, Gurr K, Horváth A, Yuan L, Lemoine MD, Schulz C, Sani J, Petersen J, Reichenspurner H, Kirchhof P, Jespersen T, Eschenhagen T, Hansen A, Koivumäki JT, Christ T, Cells, 08/05/22, 11, 15, 2424, 10.3390/cells11152424, 35954268, PMC9368200
• Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model: Opportunities and challenges-The Hamburg perspective, Ismaili D, Schulz C, Horváth A, Koivumäki JT, Mika D, Hansen A, Eschenhagen T, Christ T, Front Physiol, 02/16/23, 14, 1132165, 10.3389/fphys.2023.1132165, 36875015, PMC9978010
• KCNQ1 suppression-replacement gene therapy in transgenic rabbits with type 1 long QT syndrome, Sahej Bains, Lucilla Giammarino, Saranda Nimani, Nicolo Alerni, David J Tester, C S John Kim, Nicolas Christoforou, Julien Louradour, András Horváth, Olgica Beslac, Miriam Barbieri, Lluis Matas, Thomas S Hof, Ruben Lopez, Stefanie Perez-Feliz, Chiara Parodi, Luisana G Garcia Casalta, Jacqulyn Jurgensen, Michael A Barry, Mariana Bego, Lisa Keyes, Jane Owens, Jason Pinkstaff, Gideon Koren, Manfred Zehender, Michael Brunner, Daniela Casoni, Fabien Praz, Andreas Haeberlin, Gabriel Brooks, Michael J Ackerman, Katja E Odening, European Heart Journal, 09/21/24, 45, 36, 3751–3763, 10.1093/eurheartj/ehae476

• Simula Summer School, Oslo, Norway and San Diego, USA, 2015
• Communicating Scientific Research course, Oslo, Norway, 2016
• Industrial Workshop, Copenhagen, Denmark, 09/12/17 - 09/15/17
• Cardiac Electrophysiology Summer School Basic and clinical aspects, Copenhagen, Denmark, 2017
• Scientific Innovation workshop from Christian Hackl, Oslo, Norway, 2017, 2018
• Leadership workshop by Katrine Borgen, Oslo, Norway, 2018

• Faculty of Science and Informatics, University of Szeged Student’s Conference, Szeged, 2010, 2nd prize
• XXX. National Student’s Conference, Budapest, 2011, Special prize
• Faculty of Medicine, University of Szeged Student’s Conference, 2011, 3rd prize
• The 75th Anniversary of Albert-Szent Györgyi’s Nobel Prize award, Szeged, 2011, Poster
• 36th Meeting of the European Working Group on Cardiac Cellular Electrophysiology, Nantes, France, 2012, Poster
• 8th YES Meeting, Porto, Portugal, 2013, Plenary Presentation, 1st Prize
• Conference „Wind Spring” for PhD Students, Sopron, 2013, Oral Presentation
• Congress of the Hungarian Society of Pharmacology and Physiology, Budapest, 2013, Poster
• Congress of the Hungarian Society of Cardiology, Balatonfüred, 2014, Oral Presentation, Young investigator award, 3rd Prize
• 38th Meeting of the European Working Group on Cardiac Cellular Electrophysiology, Maastricht, Netherlands, 2014, Poster
• Congress of the Hungarian Society of Cardiology, Balatonfüred, 2015, Oral Presentation
• 81st Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology, Kiel, 2015, Poster
• Ion Channel Symposium, Copenhagen, Denmark, 2015
• EHRA Europace Cardiostim, Milan, Italy, 2015, Poster
• 40th Meeting of the European Working Group on Cardiac Cellular Electrophysiology, Glasgow, UK, 2016, Poster
• Congress of the Hungarian Society of Cardiology, Balatonfüred, 2016, Oral Presentation
• Congress of the Hungarian Society of Cardiology, Balatonfüred, 2017, Oral Presentation
• 14th Dutch-German Joint Meeting of the Molecular Cardiology Groups, Münster, Germany, 2017, Poster
• Cardiac Ion Channel Symposium, Copenhagen, Denmark, 2017
• EHRA Europace cardiostim, Vienna, Austria, 2017, Oral Presentation
• 42nd Meeting of the European Working Group on Cardiac Cellular Electrophysiology, Essen, Germany, 2018, Poster
• EHRA Europace Cardiostim, Lisbon, Portugal, 2019, Poster
• KV7 Symposium, Naples, Italy, 2019, Poster
• 46th Meeting of the European Working Group on Cardiac Cellular Electrophysiology, Toledo, Spain, 2022, Poster
• 47th Meeting of the European Working Group on Cardiac Cellular Electrophysiology, Copenhagen, Denmark, 2023, Poster
• LS2 Ion Channel and Membrane Transporters Meeting, Bern, Switzerland, 2022, Oral Presentation
• Annual Meeting of the Biophysical Society, Philadelphia, USA, 2024, Oral Presentation

• Martial Arts
• Travel
• Sports
• Outdoor activities (hiking, biking, fishing, skiing)