Priyanshu M. Sinha
Preclinical Scientist | Translational Research
Aarhus
Summary
Dedicated and driven scientist with a strong background in preclinical research, specializing in oncology, radiobiology, and immunology. Skilled in designing, executing, and documenting high-quality in vivo studies using mouse tumor models. Proficient in various techniques such as tissue collection, biomarker analysis (including flow cytometry and ELISA), and histological methods. Experienced in in vitro approaches, including primary cell culture and organoid systems.
Overview
10
10
years of professional experience
6
6
years of post-secondary education
3
3
Languages
Work History
RESEARCHER PHD STUDENT (FULL TIME) AND RESEARCH ASSISTANT (PART TIME)
Aarhus University
09.2021 - 03.2025
- Company Overview: Marie Skłodowska-Curie Actions - Innovative Training Network (MSCA-ITN) Fellow (grant Hyperboost - boosting effects of radiotherapy). https://hyperboost.eu/
- Investigated the additive/synergistic effects of combining ionizing radiation (photons and protons) on cancers using mouse tumor and normal tissue models.
- Focused on the establishment of hypofractionated radiation and hyperthermia, optimizing treatment intervals and applied temperatures.
- Investigated the underlying mechanisms for their synergy that includes such as hypoxia, and DNA damage, and assessed hyperthermia as an adjuvant for FLASH radiation.
- Conducted normal tissue studies to evaluate potential toxicity for determining overall therapeutic benefit.
- Research interests include oncology, immunology, particle therapy, tumor microenvironment, hyperthermia, stereotactic radiation, hypoxia, and DNA damage.
- Marie Skłodowska-Curie Actions - Innovative Training Network (MSCA-ITN) Fellow (grant Hyperboost - boosting effects of radiotherapy). https://hyperboost.eu/
- Full time PhD Student position held till 30th November, 2024.
- Held a research assistant position from 1st December 2024 to 31st March 2025 (part time).
- Successfully defended my PhD on 12th March, 2024.
ACADEMIC/STUDENT ASSISTANT (HIWI)
Max Planck Institute of Brain Research
03.2019 - 03.2021
- Computational reconstruction of 3D electron microscopy data (Brain Images) using online software tool (Webknossos).
- This involve identifying and tracing of specialised cellular components.
- Duration of work: 01-04-2019 to 30-09-2020 and 1-01-2021 to 31-03-2021.
ACADEMIC ASSISTANT (HIWI)/MASTER THESIS STUDENT
Georg Speyer Haus, Institute of Tumor Biology and Experimental Therapy
02.2020 - 02.2021
- Project Title: Modeling Adaptive Immune responses in patient derived colorectal cancer organoids.
- This study developed and optimized 3D co-culture models using patient-derived tumor organoids (PDTOs) and both primary and CAR-engineered CD8+ T cells to evaluate immune responses in colorectal cancer.
- Key findings include successful T cell expansion with a desirable stem/memory phenotype, identification of compatible culture conditions, and CAR-T cell-mediated organoid cytotoxicity.
- The work establishes a platform for personalized, high-throughput immunotherapy testing.
- Master thesis Grade: 1.5 (German Scale).
- 3D Cell/Organoid Culture; Flow Cytometry panel design and analysis; PBMC isolation and culture; Immunophenotyping; T Cell Organoid Coculture; Lentiviral Transduction; Luciferase Assay.
MASTER STUDENT ASSISTANT
Institute of Cell Biology and Neuroscience, Goethe University
09.2019 - 11.2019
- Assisted in cell culture practical course by mentoring first year master students in their laboratory work.
- Also planned and prepared the required reagents required for the cell culture practical course.
IGEM TEAM MANCHESTER GRAZ 2015
Manchester Institute of Biotechnology
11.2014 - 08.2015
- Lab team member: planned and carried out scientific investigations that includes performing standard lab techniques for preparation, transformation and characterization of engineered bacterial plasmids.
- Developed HPLC methods to separate compounds involved in metabolic pathway of Dopamine in engineered bacteria.
- Administrative activities include: Communicating to academics and companies for funding, maintaining file for finances, lab consumables, conference registration.
- Assisted in making the team presentation, team wiki page and engaged in outreach activities.
- Modeling Team Leader: Quantitatively determined the effects of diet sources on the synthesis of Dopamine and its derivative using computational approach.
Education
MSC - PHYSICAL BIOLOGY OF CELLS AND CELL INTERACTIONS
Goethe University Frankfurt am Main
10.2018 - 01.2021
MENG (HONS) - BIOMATERIALS SCIENCE AND TISSUE ENGINEERING
The University of Manchester
09.2012 - 06.2016
Skills
Cell culture
Microscopy
FACS
Molecular biology
Critical thinking
Data analysis
Attention to detail
MS office
Documentation and reporting
Scientific writing
Research planning
Quantitative research
Qualitative and quantitative research
Research presentation
Personal Information
- Nationality: Indian
- Work Permit: Danish
Timeline
RESEARCHER PHD STUDENT (FULL TIME) AND RESEARCH ASSISTANT (PART TIME)
Aarhus University
09.2021 - 03.2025
ACADEMIC ASSISTANT (HIWI)/MASTER THESIS STUDENT
Georg Speyer Haus, Institute of Tumor Biology and Experimental Therapy
02.2020 - 02.2021
MASTER STUDENT ASSISTANT
Institute of Cell Biology and Neuroscience, Goethe University
09.2019 - 11.2019
ACADEMIC/STUDENT ASSISTANT (HIWI)
Max Planck Institute of Brain Research
03.2019 - 03.2021
MSC - PHYSICAL BIOLOGY OF CELLS AND CELL INTERACTIONS
Goethe University Frankfurt am Main
10.2018 - 01.2021
IGEM TEAM MANCHESTER GRAZ 2015
Manchester Institute of Biotechnology
11.2014 - 08.2015
MENG (HONS) - BIOMATERIALS SCIENCE AND TISSUE ENGINEERING
The University of Manchester
09.2012 - 06.2016
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