Viktor Hundtofte Mebus

I have a PhD from the University of Copenhagen in the Department of Veterinary and Animal Sciences, under the supervision of Dorte Frees.

I have worked on projects aimed at characterizing the mechanisms by which bacteria develop resistance. In this work, I have used a variety of molecular biology techniques, including cloning, Northern and Western blotting, as well as a range of microscopy techniques such as immunofluorescence, fluorescence, time-lapse, electron, and super-resolution (SR-SIM) microscopy.

I have also contributed to setting up a system for tracking the growth of multiple bacterial strains simultaneously and have experience using Fiji for image analysis. My greatest strengths lie in the laboratory work, optimizing workflows for practical applications.

Best poster award - Europneumo 2023 - Crete

Co-authorships:

Bæk, K. T., Jensen, C., Farha, M. A., Nielsen, T. K., Paknejadi, E., Mebus, V. H., . . . Frees, D. (2021). A Staphylococcus aureus clpX Mutant Used as a Unique Screening Tool to Identify Cell Wall Synthesis Inhibitors that Reverse β-Lactam Resistance in MRSA. Front Mol Biosci, 8, 691569. doi:10.3389/fmolb.2021.691569

Nielsen, T. K., Petersen, I. B., Xu, L., Barbuti, M. D., Mebus, V., Justh, A., . . . Frees, D. (2024). The Spx stress regulator confers high-level β-lactam resistance and decreases susceptibility to last-line antibiotics in methicillin resistant Staphylococcus aureus. bioRxiv, 2024.2003.2001.582999. doi:10.1101/2024.03.01.582999

Xu, L., Henriksen, C., Mebus, V., Guérillot, R., Petersen, A., Jacques, N., . . . Frees, D. (2023). A Clinically Selected Staphylococcus aureus clpP Mutant Survives Daptomycin Treatment by Reducing Binding of the Antibiotic and Adapting a Rod-Shaped Morphology. Antimicrob Agents Chemother, 67(6), e0032823. doi:10.1128/aac.00328-23